Notes in RBC HEM

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Published	08/21/2024
Published	08/21/2024	Let’s take another look at Hematology workflow in the lab:1.Physician orders a ______ (which includes a _______)2.Sample is _______ and then3.Sample i…
Published	08/21/2024	Hema Lab Test: 1. Which ones are routine ? (2)2. Which ones are advanced? (4) 3. Which ones are additional? (4)
Published	08/21/2024	Specimen Handling Requirements: 1. What kind of specimen? From where? 2. Blood from where or where are acceptable? Smear made where? 3.…
Published	08/21/2024	What are considered unacceptable specimens? 1. Name the three categories for unacceptable specimens
Published	08/21/2024	What are considered unacceptable specimens? 1. Partially or underfilled tubes (aka ______) 1. What is important? 1a.  ____ = too m…
Published	08/21/2024	What are considered Unacceptable Specimens? 2. Over-Filled Tubes1. Would only occur if ________ from ______2. Prevents ______ of sample = _____&n…
Published	08/21/2024	What are considered Unacceptable Specimens? Overexposure to EDTA 1. PBF should be made within how many hours? 2. Cells in EDTA more tha…
Published	08/21/2024
Published	08/21/2024	Unacceptable Specimens for PBFs________(1)_____ Venipuncture_________ draws or _______ ______ tubes means ____________________or _________ may _______…
Published	08/21/2024	Peripheral Blood Film examination Staining the PBF using ________ stains:1. Are they polychromatic? What stains (2)2. Free methylene blue is ____…
Published	08/21/2024	Hematopoiesis1. Includes what 3 steps? 2. What about BM? 3. Governed by what with ___- and ____ capability4. HSC constitutes only ___ of all…
Published	08/21/2024	Draw the hematopoiesis cell line:
Published	08/21/2024	Draw the hematopoiesis cell line again with growth factors
Published	08/21/2024	Phase of hematopoiesis1. What are the 3 phases of hematopoiesis? 2. Describe them
Published	08/21/2024	Erythropoiesis: RBC production, function  Starts with differentiation of ____ to ____, which one is less responsive to ____? ____ diffe…
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Published	08/21/2024	RBC review Metabolism1. What is glycolysis (___ path) aka ___ pathway. Glucose (from where) ___ enteres RBC as what? What molecules are produced?…
Published	08/21/2024	Membrane structure and functionComposition: name percentages (3)Membrane _____: is it important?Transmembrane (integral) proteins (4)Cytoskeletal (per…
Published	08/21/2024	Hb synthesis and function•How many % of cytoplasmic content, concentration within what? 2. Chains3. how many genes encode for Hb chains? On what …
Published	08/21/2024	1. Hb function: what is it? (2)2. O2 easily where? 3. HbO2 and O2 tension correlation (sigmoid shape of the O2 dissociation curve)4. Name A, B, a…
Published	08/21/2024	Know these :
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Published	08/21/2024	Case 1:Before treatment:
Published	08/21/2024	Case 2An 85-year-old slender, frail white woman was hospitalized for diagnosis and treatment of anemia suspected during a routine examination by her p…
Published	08/21/2024	Case 3A 70-year-old female patient visited her doctor complaining of  shortness of breath on exertion, fatigue, and lassitude for past 2 to 3 mon…
Published	08/21/2024	Case 4 and 5
Published	08/21/2024	Case 6
Published	08/21/2024	Lecture 2: Anemias : Hypoproliferative (role of iron)Overview: •Iron kinetics •Iron deficiency anemia •Sideroblastic anemia •Anemia of chronic …
Published	08/21/2024	Iron Absorption and Storage
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Published	08/21/2024	Iron Absorption and Storage
Published	08/21/2024	Iron Deficiency Anemia 1. Etiology (4)2. Pathogenesis : List the 3 stages of IDA3. Lab Diagnosis : list the screening tests (1, 5*), diagnostic t…
Published	08/21/2024	Iron Deficiency Anemia (IDA) Case studies
Published	08/21/2024	Case 2An 85-year-old slender, frail white woman was hospitalized for diagnosis and treatment of anemia suspected during a routine examination by her p…
Published	08/21/2024	Case 3 A 70-year-old female patient visited her doctor complaining of  shortness of breath on exertion, fatigue, and lassitude for past 2 to…
Published	08/21/2024	Anemia of Chronic Inflammation1. What does is associate with? What kind of disease? List the diseases (4) 2. PBS findings: 3. Iron studies:&…
Published	08/21/2024	Sideroblastic anemia 1. What disorder is this? caused by what? what stain is used , shows what, in where, surrounding what? Is it hereditary/acqu…
Published	08/21/2024	Results of Iron Studies in MICROCYTIC Anemias
Published	08/21/2024	Case studies 4 and  5
Published	08/21/2024	Case 6
Published	08/21/2024	•Algorithm for preliminary investigation of macrocytic anemias
Published	08/21/2024	Vit B12 Physiology1. What's the other name of Vit B12? 2. Vit B-12 structure3. Several forms (2)4. Vit B12 is important through 2 pathways: what …
Published	08/21/2024	Folate Physiology: (About folate and what it does)1. Vitamin form is ______2. General term is ______3. Consists of 3 things: ______ + ______ + ______4…
Published	08/21/2024	Vitamin B12 Physiology:1. Vitamin B12 is also known as ______2. Describe the structure of Vitamin B123. What two forms are found in foods?4. What two …
Published	08/21/2024	Pernicious Anemia 1. Disease type: ____ disease in which an ______ is _______ against ___ or _____ cells 2. Mechanism : Through ______ respo…
Published	08/21/2024	MEGALOBLASTIC ANEMIA: LAB DIAGNOSIS1. Anemia develops ___ but usually very ____ (Hb___) 2. Earliest sign: 3. MCV: ____ , mostly ___4. RBC di…
Published	08/21/2024	Vitamin B12 absorption:Impaired absorption may occur in any of these steps:1. Vitamin B12 fails to separate from ______ in the stomach, e.g. due to __…
Published	08/21/2024	Schilling Test1. function2. causes3. methods4. Patient methods: the patient is given what? -What is the name of the injection?-What is the purpose of …
Published	08/21/2024	Folate and B12 role in dna metabolism:Folate trap:1. When B12 is deficient, a large amount of ______ will be trapped in the form of ______, because it…
Published	08/21/2024	Megaloblastic Anemia: Lab Diagnosis (Screening tests and specific diagnostic tests)
Published	08/21/2024	Clinical symptoms Vitamin B12 and Folate deficiency:•In vit B12 deficiency, neurologic symptoms are more prominent, such as ______, ______, ______. •I…
Published	08/21/2024	Megaloblastic anemia: lab diagnosis
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