Notes in Week 3 Pharm pt 2

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Status	Last Update	Fields
Published	02/28/2025	Lidocaine adverse effects:{{c1::Narrow theraputic index}}CNS symptoms of overdose → {{c1::drowsiness, irritability, convulsions::3}}
Published	02/28/2025	Flecainide MOA: Class {{c1::IC}}; Stabilizes {{c1::Na+}} channel {{c1::inactive}} form, plus some {{c1::K+}} channel inhibitionLarge reduction in {{c1…
Published	02/28/2025	Flecainide therapeutics:Primary: Oral treatment of {{c1::supraventricular tachyarrhythmias}}Secondary: Oral treatment to prevent {{c1::premature}} ven…
Published	02/28/2025	Flecainide adverse effects:Contraindicated with previous {{c1::myocardial infarction}} due to risk of {{c1::ventricular}} fibrillation
Published	02/28/2025	Procainamide therapeutics:{{c1::Ventricular and supraventricular::2}} arrhythmias
Published	02/28/2025	Procainamide adverse effects:Prolonged {{c1::QT}} interval{{c1::Hypersensitivity}} reactions
Published	02/28/2025	Dofetilide therapeutics:{{c1::Supraventricular}} tachycardia and {{c1::atrial}} fibrillation (oral)
Published	02/28/2025	Dofetilide adverse effects:Long {{c1::QT}} interval and {{c1::ventricular}} arrhythmias (adjust dosing)Excreted from the {{c1::kidney}}. Caution for p…
Published	02/28/2025	Amiodarone therapeutics:Recurrent {{c1::ventricular}} tachycardia or fibrillation (high dose)Conversion of {{c1::ventricular}} arrhythmias (IV)Resista…
Published	02/28/2025	Sotalol adverse effects:Long {{c1::QT}} interval and {{c1::ventricular}} arrhythmias{{c1::Renal}} excretion, caution for patients with poor {{c1::rena…
Published	02/28/2025	Metoprolol adverse effects:{{c1::Bradycardia}}{{c1::AV}} block{{c1::Fatigue}}{{c1::Bronchoconstriction}}
Published	02/28/2025	Adenosine MOA: {{c1::Adenosine receptor agonist}}↓ {{c1::cAMP}} and activates {{c1::KV}} channelsSA and atria: ↓ {{c1::automaticity}}AV node: ↓ {{c1::…
Published	02/28/2025	Adenosine therapeutics:Acute conversion of {{c1::re-entrant supraventricular}} tachycardias ({{c1::AVNRT/AVRT::2}})Blocks impulse re-entry from {{c1::…
Published	02/28/2025	Verapamil / Diltiazem MOA: Class {{c1::IV}}; Cardiac {{c1::Cav}} channel {{c1::inhibitor}}{{c1::Frequency}}-dependent block of {{c1::calcium}} cu…
Published	02/28/2025	Verapamil / Diltiazem therapeutics:Primarily {{c1::supraventricular}} arrythmias{{c1::Atrial flutter and fibrillation::2}}{{c1::Paroxysmal supraventri…
Published	02/28/2025	Verapamil is a {{c1::phenylalkylamine::chemical class}}Diltiazem is a {{c1::benzothiazepine::chemical class}}
Published	02/28/2025	Digoxin MOA: Cardiomyocyte {{c1::Na+/K+ ATPase}} pump {{c1::competitive inhibitor}} (cardiac glycoside)Disrupts the cardiomyocyte {{c1::electrochemica…
Published	02/28/2025	Digoxin therapeutics:{{c1::Systolic}} heart failureRate control of {{c1::atrial fibrillation and atrial flutter::2}}
Published	02/28/2025	Digoxin adverse effects:Extremely narrow {{c1::therapeutic index}} (~2) due to the ubiquitous expression and generalized importance of the {{c1::Na+/K…
Status	Last Update	Fields